Which of the following statements is correct?
Osteoporosis is a disease with a weak genetic component
Most genetic research has focused on fracture markers
LRP5 variants are rare but have a large effect on BMD regulation
Osteogenesis imperfecta is a disease caused by mutations in more than 5 genes
Family studies show low heritability of osteoporosis-related traits
What methods are currently used to identify osteoporosis susceptibility genes?
Analysis of bone remodelling markers
QWAS
GWAS
Studies on candidate genes
All the above items
What GWAS means?
Graded way of applied study
Genome-wide associated scanning
Genome-wide association study
Genetic way of applying science
Global warming associated syndrome
What percentage of peak bone mass is genetically determined?
20-40%
25-45%
30-50%
50-85%
60-90%
Which of the following is a rare monogenic bone disease caused by mutations in the LRP5 gene?
Osteopetrosis
Sclerosteosis
Osteoporosis-pseudoglioma syndrome
van Buchem disease
Pycnodysostosis