In glucocorticoid-induced osteoporosis (GIOP), all are correct except for
GIOP is a cause of secondary osteoporosis in young people
Fracture occurs at a higher BMD
Glucocorticoids inhibit osteoblast formation and differentiation and induce apoptosis
11-β hydroxy steroid dehydrogenase (11B-HSD) is the enzyme that determines the degree of increased bone formation
An indirect effect of glucocorticoids on bone is an increase in intestinal absorption of calcium
With regard to osteoporosis induced by tumour therapy, which of the following statements is correct?
Aromatase inhibitors reduce oestrogen levels
A T-score < -1.0 in premenopausal women with ovarian suppression on aromatase inhibitor for breast cancer is an indication for initiation of antiresorptive therapy
Bone is often the least frequent site of distant metastases in prostate cancer
Teriparatide is the first choice for the treatment of osteoporosis in patients undergoing androgen deprivation therapy for prostate cancer
a and b
Which of the following statements is correct?
NSAIDs are considered as part of Fall Risk Increasing Drugs (FRIDs)
Opioids are associated with an increased risk of fracture
Opioids can reduce BMD by causing secondary hypogonadism
Selective serotonin reuptake inhibitor (SSRI) use is associated with an increased risk of fractures
All the above
What is the most common form of secondary osteoporosis?
Drug-induced osteoporosis from chemotherapy
Glucocorticoid-induced osteoporosis (GIOP)
Osteoporosis caused by androgen deprivation therapy
Osteoporosis due to selective serotonin reuptake inhibitors (SSRIs)
Osteoporosis due to proton pump inhibitors (PPI)
What is the primary mechanism by which glucocorticoids cause bone loss?
Decreased osteocyte apoptosis
Inhibition of osteoblast formation and differentiation
Enhanced calcium absorption in the gut
Reduced osteoclast activity
Decreased osteoblastic apoptosis
What is the most widely used treatment for GIOP patients at risk of fractures?
Teriparatide
Oral bisphosphonates
Denosumab
Oestrogen
SERM